Search results for " SEPTIC SHOCK"

showing 10 items of 11 documents

Epidemiology of intra-abdominal infection and sepsis in critically ill patients: "AbSeS", a multinational observational cohort study and ESICM Trials…

2019

Pardo-Oviedo, Juan Mauricio/0000-0003-0084-3449; Lopez-Delgado, Juan Carlos/0000-0003-3324-1129; Corradi, Francesco/0000-0002-5588-2608; De Backer, Daniel/0000-0001-9841-5762; POTA, VINCENZO/0000-0001-9999-3388; Tomescu, Dana/0000-0001-9673-5754; Sabetian, Golnar/0000-0001-8764-2150; Girardis, Massimo/0000-0002-2453-0829; Brazzi, Luca/0000-0001-7059-0622; Leone, Marc/0000-0002-3097-758X; Zabolotskikh, Igor Borisovich/0000-0002-3623-2546; De Lange, Dylan/0000-0002-0191-7270; ALMEKHLAFI, GHALEB A./0000-0002-0323-7025; Elke, Gunnar/0000-0002-4948-1605; Grigoras, Ioana/0000-0001-9412-9574; Czuczwar, Miroslaw/0000-0002-9025-6717; Nora, David/0000-0002-1133-7368; Masjedi, Mansoor/0000-0001-6175-9…

Infection riskMaleBIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences.Antibiotic resistanceTracte gastrointestinal - MalaltiesDefinitionsCritical Care and Intensive Care MedicineTHERAPYDEFINITIONS:Infections::Intraabdominal Infections [DISEASES]0302 clinical medicineIntensive care; Intra-abdominal infection; Mortality; Multidrug resistance; Peritonitis; Sepsis;[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseasesObservational studySeptic shockIntensive care; Intra-abdominal infection; Mortality; Multidrug resistance; Peritonitis; SepsisComputingMilieux_MISCELLANEOUSCritical Illness/epidemiology[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseasesBIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti.Intraabdominal Infections/epidemiologyAbdominal infectionMulticenter study3. Good healthManagementClinical trialCohort[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/VirologyCohort analysisCommunity acquired infectionCohort studyHumanmedicine.medical_specialtyCarbapenem resistanceCritical IllnessPeritoneal dialysisPeritonitisVancomycin resistant enterococcusMajor clinical studyPeritonitisArticle03 medical and health sciencesAntibiotic resistance[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemIntensive careSepsisSettore MED/41 - ANESTESIOLOGIAHumansCritical care medicineHospital infectionAgedScience & TechnologyLiver failureAntibiotic therapymedicine.disease[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/BacteriologyEpidemiologic Studies030228 respiratory systemIntensive Care Unit; Sepsis (Diptera); Septic ShockRisk factorHuman medicineGeneral & internal medicineCongestive heart failureOriginalMultidrug resistanceCohort StudiesRisk FactorsCause of DeathEpidemiologyPrevalenceMedicine and Health SciencesAbdominal abscessSepsis/epidemiologyMiddle agedAntifungal therapy2. Zero hungerPeritonitiAntibiotic agentBiliary tract infectionIntensive care ; Intra-abdominal infection ; Mortality ; Multidrug resistance ; Peritonitis ; SepsisMiddle Aged:infecciones bacterianas y micosis::infección::infecciones intraabdominales [ENFERMEDADES]PREVALENCE:Infections::Sepsis [DISEASES]:técnicas de investigación::métodos epidemiológicos::características de los estudios epidemiológicos::estudios epidemiológicos::estudios de cohortes [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS]Methicillin resistant staphylococcus aureusRaonament basat en casosFemaleCritically ill patientLife Sciences & BiomedicineAntifungal agentAdult:Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics::Epidemiologic Studies::Cohort Studies [ANALYTICAL DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT]Predictive value:infecciones bacterianas y micosis::infección::sepsis [ENFERMEDADES]NOSepsisIntra-abdominal infectionCritical Care MedicineInternal medicineGeneral & Internal MedicinemedicineMANAGEMENTJournal Article[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/ParasitologySepticèmiaMortalitybusiness.industrySeptic shockPancreas diseaseMalnutrition030208 emergency & critical care medicineTyphlitisToxic megacolonIntensive careIntraabdominal InfectionsTherapyLate onset disorderbusiness
researchProduct

Good clinical practice for the use of vasopressor and inotropic drugs in critically ill patients: state-of-the-science and expert consensus

2021

Vasopressors and inotropic agents are widely used in critical care. However, strong evidence supporting their use in critically ill patients is lacking in many clinical scenarios. Thus, the Italian Society of Anesthesia and Intensive Care (SIAARTI) promoted a project aimed to provide indications for good clinical practice on the use of vasopressors and inotropes, and on the management of critically ill patients with shock. A panel of 16 experts in the field of intensive care medicine and hemodynamics has been established. Systematic review of the available literature was performed based on PICO questions. Basing on available evidence, the panel prepared a summary of evidences and then wrote…

Inotropemedicine.medical_specialtyConsensusCritical CareCritical IllnessMEDLINEshockCardiotonic AgentsCardiotonic agentsVasoconstrictor agentsCardiogenic shock; Cardiotonic agents; Septic shock; Vasoconstrictor agents03 medical and health sciences0302 clinical medicineVasoconstrictor agents030202 anesthesiologySeptic shockIntensive caremedicineHumansVasoconstrictor AgentsIntensive care medicineCardiogenic shockbusiness.industrySeptic shockCardiogenic shock030208 emergency & critical care medicinemedicine.diseaseAnesthesiology and Pain MedicinePharmaceutical PreparationsShock (circulatory)Good clinical practicemedicine.symptombusinessCardiotonic agents
researchProduct

Higher Fluid Balance Increases the Risk of Death From Sepsis: Results From a Large International Audit

2017

Contains fulltext : 177598.pdf (Publisher’s version ) (Closed access) OBJECTIVES: Excessive fluid therapy in patients with sepsis may be associated with risks that outweigh any benefit. We investigated the possible influence of early fluid balance on outcome in a large international database of ICU patients with sepsis. DESIGN: Observational cohort study. SETTING: Seven hundred and thirty ICUs in 84 countries. PATIENTS: All adult patients admitted between May 8 and May 18, 2012, except admissions for routine postoperative surveillance. For this analysis, we included only the 1,808 patients with an admission diagnosis of sepsis. Patients were stratified according to quartiles of cumulative f…

InternationalityTime FactorsDatabases Factualmedicine.medical_treatmentlnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]Settore MED/41 - AnestesiologiaCritical Care and Intensive Care Medicinelaw.invention0302 clinical medicinelawRisk Factors80 and over030212 general & internal medicineHospital Mortality610 Medicine & healthAged 80 and overMedical Auditfluid outputMiddle AgedWater-Electrolyte Balancefluid administrationIntensive care unitfluid administration; fluid output; outcome; septic shock; Adult; Aged; Aged 80 and over; Databases Factual; Hospital Mortality; Humans; Intensive Care Units; Internationality; Medical Audit; Middle Aged; Risk Factors; Sepsis; Time Factors; Fluid Therapy; Water-Electrolyte Balance; Critical Care and Intensive Care MedicineIntensive Care UnitsCohortoutcomeHumanCohort studyAdultmedicine.medical_specialtyTime FactorSepsiIntensive Care UnitObservational StudySepsis03 medical and health sciencesDatabasesSepsisHemofiltrationmedicineJournal ArticleHumansRisk factorIntensive care medicineFactualHetastarchAgedbusiness.industrySeptic shockRisk Factor030208 emergency & critical care medicinefluid administration fluid output outcome septic shockmedicine.diseaseseptic shockFluid Therapybusiness
researchProduct

Albumin replacement in patients with severe sepsis or septic shock.

2014

BACKGROUND: Although previous studies have suggested the potential advantages of albumin administration in patients with severe sepsis, its efficacy has not been fully established. METHODS: In this multicenter, open-label trial, we randomly assigned 1818 patients with severe sepsis, in 100 intensive care units (ICUs), to receive either 20% albumin and crystalloid solution or crystalloid solution alone. In the albumin group, the target serum albumin concentration was 30 g per liter or more until discharge from the ICU or 28 days after randomization. The primary outcome was death from any cause at 28 days. Secondary outcomes were death from any cause at 90 days, the number of patients with or…

Malemedicine.medical_specialtyALBUMIN SEPSIS SEVERE SEPSIS SEPTIC SHOCKSepsiSerum albuminSettore MED/41 - AnestesiologiaAged; Albumins; Female; Humans; Isotonic Solutions; Male; Middle Aged; Rehydration Solutions; Sepsis; Serum Albumin; Shock Septic; Survival Rate; Treatment OutcomeSepsisIntensive careAlbuminsSepsismedicineHumansalbumin replacementSurvival rateSerum AlbuminIsotonic SolutionAgedAged; Albumins; Female; Humans; Isotonic Solutions; Male; Middle Aged; Rehydration Solutions; Sepsis; Serum Albumin; Shock Septic; Survival Rate; Treatment Outcome; Medicine (all)SEPSISbiologybusiness.industrySeptic shockRehydration SolutionSepticMedicine (all)AlbuminSEPTIC SHOCKOrgan dysfunctionAlbuminShockGeneral MedicineMiddle Agedmedicine.diseaseShock SepticSurgerySurvival RateTreatment OutcomeAnesthesiaRelative riskRehydration Solutionsbiology.proteinFemalemedicine.symptomIsotonic SolutionsbusinessHuman
researchProduct

Building a continuous multicenter infection surveillance system in the intensive care unit: findings from the initial data set of 9,493 patients from…

2008

OBJECTIVE: To describe the epidemiology of infections in intensive care units (ICUs), whether present at admission or acquired during the stay. METHODS: Prospective data collection lasting 6 months in 71 Italian adult ICUs. Patients were screened for infections and risk factors at ICU admission and daily during their stay. MAIN RESULTS: Out of 9,493 consecutive patients admitted to the 71 ICUs, 11.6% had a community-acquired infection, 7.4% a hospital-acquired infection, and 11.4% an ICU-acquired infection. The risk curve of acquiring infection in the ICU was higher in patients who entered without infection than in those already infected (log-rank test, p < .0001; at 15 days, 44.0% vs. 34.6…

Resuscitationmedicine.medical_specialtyMedical Records Systems ComputerizedQuality Assurance Health Carehealth care facilities manpower and servicescritically illCritical Care and Intensive Care MedicineInfectionslaw.inventioncritical care medicine sepsis infectious diseaselawRisk FactorsIntensive careEpidemiologymedicineInfection controlHumansHospital MortalityProspective StudiesIntensive care medicineInfection surveillancebusiness.industrySeptic shockIncidenceLength of StayMiddle Agedmedicine.diseasePrognosisIntensive care unitinfection controlinfectionIcu admissionsevere sepsisSurvival RateIntensive Care Unitsinfection control controlLogistic ModelsItalyPopulation Surveillanceseptic shockbusinessintensive care units critically ill infection infection control severe sepsis septic shockCritical care medicine
researchProduct

Global validation of the WSES Sepsis Severity Score for patients with complicated intra-abdominal infections : a prospective multicentre study (WISS …

2015

BACKGROUND: To validate a new practical Sepsis Severity Score for patients with complicated intra-abdominal infections (cIAIs) including the clinical conditions at the admission (severe sepsis/septic shock), the origin of the cIAIs, the delay in source control, the setting of acquisition and any risk factors such as age and immunosuppression. ----- METHODS: The WISS study (WSES cIAIs Score Study) is a multicenter observational study underwent in 132 medical institutions worldwide during a four-month study period (October 2014-February 2015). Four thousand five hundred thirty-three patients with a mean age of 51.2 years (range 18-99) were enrolled in the WISS study. ----- RESULTS: Univariate…

medicine.medical_specialtyInfections; Intra-abdominal; Sepsis; Septic shock:Ciências da Saúde [Ciências Médicas]Infections; Intra-abdominal; Sepsis; Septic shock; Surgery; Emergency MedicineCiências Médicas::Ciências da SaúdeSepsimedicine.medical_treatment/macromolecular substances030230 surgeryGUIDELINESInfectionsLikelihood ratios in diagnostic testingSepsisPERITONITIS03 medical and health sciencesPROGNOSTIC-FACTORS0302 clinical medicineInternal medicineSepsisSeptic shockMedicine and Health SciencesMANAGEMENTmedicineIntra-abdominalIntra-abdominal SepsisUnivariate analysisScience & TechnologyCOLONIC PERFORATIONReceiver operating characteristicbusiness.industrySeptic shockAbdominal InfectionImmunosuppression3126 Surgery anesthesiology intensive care radiologymedicine.disease3. Good healthSurgery030220 oncology & carcinogenesisInfections Intra-abdominal Sepsis; Septic shockEmergency MedicineSurgeryObservational studyInfectionbusinessSYSTEMResearch Article
researchProduct

Higher levels of IgA and IgG at sepsis onset are associated with higher mortality: results from the Albumin Italian Outcome Sepsis (ALBIOS) trial

2021

Abstract Background The role of intravenous immunoglobulins (IVIG) during sepsis is controversial, as different trials on IVIG have observed inconsistent survival benefits. We aimed to elucidate the possible association and clinical significance between circulating levels of immunoglobulins. Methods In a subset of 956 patients with severe sepsis and septic shock of the multicentre, open-label RCT ALBIOS, venous blood samples were serially collected 1, 2, and 7 days after enrolment (or at ICU discharge, whichever came first). IgA, IgG and IgM concentrations were assayed in all patients on day 1 and in a subgroup of 150 patients on days 2 and 7. Ig concentrations were measured employing a tur…

medicine.medical_specialtySepsiIgGSecondary infectionCritical Care and Intensive Care MedicineGastroenterologylaw.inventionSepsisRandomized controlled triallawInternal medicineSepsisSeptic shockRisk of mortalitymedicineClinical significanceMortalitybusiness.industrySeptic shockRC86-88.9ResearchMedical emergencies. Critical care. Intensive care. First aidVenous bloodmedicine.diseaseIgM ImmunoglobulinsbusinessIgA; IgG; IgM Immunoglobulins; Mortality; Sepsis; Septic shockIgM ImmunoglobulinIgACohort study
researchProduct

Albumin replacement therapy in immunocompromised patients with sepsis - Secondary analysis of the ALBIOS trial

2021

Abstract Background The best fluid replacement strategy and the role of albumin in immunocompromised patients with sepsis is unclear. Methods We performed a secondary analysis of immunocompromised patients enrolled in the ALBIOS trial which randomized patients with severe sepsis or septic shock to receive either 20% albumin (target 30 g per liter or more) and crystalloid or crystalloid alone during ICU stay. Results Of 1818 patients originally enrolled, 304 (16.4%) were immunocompromised. One-hundred-thirty-nine (45.7%) patients were randomized in the albumin while 165 (54.2%) in the crystalloid group. At 90 days, 69 (49.6%) in the albumin group and 89 (53.9%) in the crystalloids group died…

medicine.medical_specialtySepsimedicine.medical_treatmentSocio-culturaleCritical Care and Intensive Care MedicineSepsisAlbumin; Immunocompromised; Immunodeficiency; Sepsis; Septic shock03 medical and health sciencesImmunocompromised Host0302 clinical medicineInternal medicineSepsisAlbuminsSeptic shockmedicineHumansImmunodeficiencyRenal replacement therapyAlbumin; Immunocompromised; Immunodeficiency; Sepsis; Septic shock; Albumins; Crystalloid Solutions; Fluid Therapy; Humans; Immunocompromised Host; Sepsis; Shock SepticImmunocompromisedMechanical ventilationSeptic shockbusiness.industrySepticAlbuminHazard ratioAcute kidney injuryAlbumin030208 emergency & critical care medicineShockCrystalloid Solutionsmedicine.diseaseShock Septic030228 respiratory systemFluid TherapySOFA scorebusiness
researchProduct

Ceftolozane/Tazobactam for Treatment of Severe ESBL-Producing

2020

Abstract Background Few data are reported in the literature about the outcome of patients with severe extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) infections treated with ceftolozane/tazobactam (C/T), in empiric or definitive therapy. Methods A multicenter retrospective study was performed in Italy (June 2016–June 2019). Successful clinical outcome was defined as complete resolution of clinical signs/symptoms related to ESBL-E infection and lack of microbiological evidence of infection. The primary end point was to identify predictors of clinical failure of C/T therapy. Results C/T treatment was documented in 153 patients: pneumonia was the most common diagnosis (n = 46…

medicine.medical_specialtyceftolozane/tazobactammedicine.medical_treatmentCRRTTazobactamEnterobacteralesEnterobacteraleInternal medicineCRRT; ESBL; Enterobacterales; ceftolozane/tazobactam; septic shockMajor ArticlemedicineClinical endpointRenal replacement therapybusiness.industrySeptic shockRetrospective cohort studyOdds ratiomedicine.diseaseCeftolozane/tazobactam; CRRT; Enterobacterales; ESBL; Septic shockAcademicSubjects/MED00290Infectious DiseasesOncologyESBLseptic shockCeftolozanebusinessEmpiric therapymedicine.drugOpen forum infectious diseases
researchProduct

Use of Thromboelastography in severe sepsis a case-control Study

2011

Thromboelastography (TEG) is a global test of coagulation that records the viscoelastic changes in blood during clot formation. Cardiosurgery and liver transplantation are established fields of application for TEG. Severe sepsis is often characterized by an imbalance of the haemostatic equilibrium between clot formation and fibrinolysis in favor of a procoagulant status, especially in the first phase. A hypocoagulant status due to coagulation factor consumption could occur later. In spite of this, the correlation between TEG and sepsis is not clearly established. Moreover, there are doubts about which TEG-detected variable is best correlated with sepsis. The aim of this study is to clarify …

medicine.medical_specialtymedicine.diagnostic_testbusiness.industrymedicine.medical_treatmentCase-control studyThromboelastography Severe Sepsis Septic ShockSettore MED/41 - AnestesiologiaLiver transplantationCritical Care and Intensive Care Medicinemedicine.diseaseClot formationThromboelastographySurgerySepsisCoagulationInternal medicineFibrinolysisPoster PresentationmedicineCardiologybusinessSevere sepsis
researchProduct